Start On I-85: Take The Exit Toward Us-70 Bus/North Durham/Downtown Durham. Merge Onto Us-70 Bus East:. Follow Signs For Downtown Durham. Turn Right Onto Holloway St: Continue Straight For About 1.5 Miles. Turn Left Onto S Alston Ave:. Drive For Approximately 0.7 Miles. Turn Right Onto Piper St: 506 Piper St Will Be On Your Right-Hand Side.